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Podocyte

Podocyte is a cell type in renal corpuscle and wraps around the capillary of the glomerulus in the kidney. Renal corpuscle filters the blood, retaining large molecules such as proteins and filtering out smaller molecules such as water, salts, and sugars in the formation of urine. Podocytes are specialized epithelial cells that reside in the visceral layer of the Bowman\'s capsule.

Cell graphic

Cell Ontology (CL) Information

    CL ID: CL_0000653

    CL definition: A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells. [database_cross_reference: GOC:tfm]

    Synonyms: glomerular visceral epithelial cell; glomerular podocyte; kidney podocyte; renal podocyte

    Cell hierarchy: glomerular visceral epithelial cell; glomerular podocyte; kidney podocyte; renal podocyte

    The cell hierarchy as defined by the Cell Ontology (CL):

podocyte hierarchy

Location - Anatomical Structure

    Podocyte wraps around the capillary of the glomerulus in the kidney.

AS1 AS2 AS3 AS4 AS5
kidney (UBERON_0002113) cortex of kidney (UBERON_0001225) outer cortex of kidney (UBERON_0002189) Glomerular Epithelium (UBERON_0004188) visceral epithelial layer (UBERON_0006852)
kidney (UBERON_0002113) renal cortex (UBERON_0001225) renal column (UBERON_0001284) Glomerular Epithelium (UBERON_0004188) visceral epithelial layer (UBERON_0006852)
kidney (UBERON_0002113) cortex of kidney (UBERON_0001225) outer cortex of kidney (UBERON_0002189) Glomerular Epithelium (UBERON_0004188) visceral epithelial layer (UBERON_0006852)
kidney (UBERON_0002113) renal cortex (UBERON_0001225) renal column (UBERON_0001284) Glomerular Epithelium (UBERON_0004188) visceral epithelial layer (UBERON_0006852)

Connections and Vicinity

     Podocytes are neighbors of many other cell types such as afferent and efferent arteriole endothelial cells, mesangial cell, etc.

    Check related connectome information: Renal Corpuscle connectome card page.

Lineage

     The kidney, including the kidney epithelial cells, arises from OSR1+ mesenchymal progenitor cells in the intermediate mesoderm. As a type of kidney epithelial cells, podocytes arise from cap mesenchyme progenitor cells and require activation of SIX2, PAX2 and WT1. Ref: Shankland et al., 2014.

Key Gene Ontology Terms associated with Podocyte

Biomarkers:

    Podocyte-related biomarkers (Ref: HuBMAP ASCT-B Tables):

Ligands expressed in Podocyte

    Coming ...

Receptors expressed in Podocyte

    Coming ...

Neighborhood cell types of Podocyte

    The neighborhood cell types of Podocyte are described in detail in the Renal Corpuscle Cell Connectome page.

(Putative) ligand-receptor target cell/structure of Podocyte

    Coming ...

Literature mined Podocyte-related gene-gene interactions

    Please find literature mined results using Ignet:

Gene Expression Profiles

    Selected podocyte-associated gene expression studies:

Pathways and Functional Maps

    Podocyte-associated pathways and functional maps:

Cell Line Cells

    The following cell lines are available:

Clinical Significance

    Many "abnormal podocyte cell morphology" (HP_0031265) phenotypes exist:

     Podocyte-related diseases also exist:

References:

Note: Your suggestions, comments, and collaborations are welcome. Thanks!